Click here for related articles. Click here for Video tutorial. Click here for example movies (see Kim et al 2014 for explanation).
News Quick links Courses Evan's favorites
Department links Main links PET Talks!
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| Yale Psychiatry Dept |
Monthly PET TALKS! |
| Interdepartmental Neuroscience Program |
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| Yale Cancer Center |
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Heather passes area exam! Moves on to 'candidacy'. |
Oct 2018 |
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Heather hosts "Off the Beaten Path"- women iu different careers. For GradSWE |
Feb 2019 |
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Evan completes 100K "Closer to Free" ride. Raises $1600 |
Sept 2018 |
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Aishwarya and Bart (and Evan and Suchita and friends) publish new finding on Kappa receptors in Alcoholism. Suppl. 1, 2, 3 |
Oct 2018 |
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Evan, Kelly, Michelle, Sherry & Ray get BIG NIH R01 grant on stress and relapse. |
Aug 2018 |
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Coverage of marijuana smoking project |
Aug 2018 |
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Evan's review of "The Gene" appears in special issue of YJBM on gene editing. |
Dec. 2017 |
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Katina completes oral exam! |
July 2018 |
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Evan discusses dopamine movies on Podacst for MIT Alumni Assoc iation |
June 2018 |
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Yasmin graduates |
May 2018 |
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Bart defends thesis! |
Dec 2017 |
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Yasmin defends thesis! |
Mar 2018 |
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Ryan and Shuo graduate! |
May 2017 |
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Heather publishes first paper! |
Oct 2017 |
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Ryan paper published in Translational Psychiatry |
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Successful end to RCR course, ENAS 508 |
May 2017 |
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Shuo paper piublished in Neuroimage |
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Successful end to Fall 2016 Semester |
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Yasmin passes Prospectus exam! |
Oct 2016 |
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Shivani passes Qualifier! |
Dec 2016 |
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Kelly wins Pioneer Award from WHRY. Evan and Kelly (and Elisa) featured in WHRY Newsletter |
Oct 2016 |
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Aishwarya's finding on Sex differences in Kappa Opioid Receptors is covered in Yale Daily News |
Oct 2016 |
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Shuo Wang successfully defends PhD thesis |
July 2016 |
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Evan and Suchitra graduate! Promoted to Full Profs with tenure |
July 2016 |
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Kelly and Evan win grant from Yale Office of Women's Health to study marijuana smoking in men and women. |
June 2016 |
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Aishwarya's paper on sex differences in Kappa receptors is accepted by AJNMMI |
May 2015 |
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Evan and Joe featured in Yale Cancer Center Breakthroughs > The Year In Review 2015 |
Jan 2016 |
(click links for detailed program) |
Evan holds international symposium on Advances in Brain Imaging in Jerusalem. Feb 29, 2016 (click link for poster)
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Feb 2016 |
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Evan receives R21 award from NIDA for collboration to do smoking studies in Israel` |
Oct 2015 |
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Evan and Kelly featured in Israeli Media
(Times of Israel) |
Feb 2016 |
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Evan and Kelly receive R01 award from NIDA to study sex differnences in medications for smoking... via Dopamine movies |
Aug 2015 |
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Succesful end to fall semester 2015 Read what people are saying about ENAS 880. (coming soon) |
Nov 2015 |
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Evan, Joe receive R01 award from NCI to study EGFR in NSCLC with 11C-erlotinib |
May 2015 |
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Evan wins Fulbright Scholar Award for teaching and research in Israel 2015/16
Read coverage in medicine.yale.edu |
2015 |
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Shuo Wang wins travel bursary to give oral presentation at BrainPET conference, Vancouver. | Mar 2015 |
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Successful end to fall semester 2014. Read what people are saying about ENAS 880/NSCI 523 | Dec 2014 |
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Read some of the Media Coverage of Dopamine Movies:
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RSNA News |
May 2015 |
Obgyn.net repints Jackie and Evan's article on dopamine movies and PD |
Jan 2015 | ||
Inostanza (Italy) |
Feb 2015 |
World Econimic Forum |
Jan 2015 |
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| Dec 2014 |
Hartford Courant |
Dec 2014 |
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Neurology Times (by Jackie and Evan Morris) |
NIDA website |
Jan 2015 |
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| Dec 2014 |
Danbury Times |
HealthCanal (Australia) |
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Kelly, Shuo, Evan and friends publish first lpntPET results in smokers in Journal of Neuroscience Full paper here |
Nov 2014 |
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Ryan Petrulli passes his Area Exam! |
Dec 2014 |
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Aishwarya's research in Malaysia featured in Yale News |
Oct 2014 |
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Ansel's paper on MefWAY is on the cover of JNM and featured in MolecularImaging,net |
Nov 2014 |
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A dopamine movie comparing a woman smoking to a man smoking. (mp4 format). Right click to download. |
Oct 2014 |
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Online course from Epigeum on mentoring. Evan interviewed. |
Dec 2013 |
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Ryan's findings with 11C-erlotinib for imaging lung cancer are featured in summary talk at SNM 2014 in St Louis |
June 2014 |
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Sarah Goldberg, Joe Contessa and Evan receive core pilot funding from YCCI to scan monkeys and humans with 11C-erlotinib | May 2014 |
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Sujin and friends publish mathematical basis for dopamine movies in Human Brain Mapping |
Mar 2014 |
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Evan gives Grand Rounds at Yale Cancer Center. (video) |
Mar 2014 |
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Evan, Molly, Ryan, Kelly, publish review paper on PET Experiments and studies of drinking in Yale Journal of Biology and Medicine | Feb 2014 |  |
Shuo and Ryan and other lab alumni have abstracts accepted to NRM 2014. |
Feb 2014 | |
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Shuo and ACSSY host Gala Celebration of Chinese New Years - see photo. | Jan 2014 |  |
Evan, Kelly and Molly Lucas publish an introductory book chapter "How to Study Smoking and Drinking with PET" | Dec 2013 | |
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Successful end to fall semester 2013. Read what people are saying about ENAS-880. |
Dec 2013 |
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Shuo Wang passes her Area Exam! |
Nov 20, 2013 |  |
Ryan Petrulli, Joe Contessa and friends have first paper accepted on imaging of mutant EGFR with 11C-erlotinib |
Nov 11, 2013 | |
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Morris lab (and Hannestad) receives NIH grant, "Endotoxin-induced inflammation affects striatal dopamine: A raclopride PET study" | Sept 2013 | |
Evan to run Phase 1 trial as part of multi-center consortium, "New Experimental Medicine Studies: Fast-Fail Trials in Mood and Anxiety Spectrum Disorders" | Aug 2013 | |
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Morris and Krishnan-Sarin Labs jointly receive NIH grant "PET imaging of Naltrexone Occupancy of Kappa Receptors in Heavy Drinkers" | July 2013 | |
Morris, Cosgrove and friends publish video article on making dopamine movies in Journal of Visualized Experiments. (video) | Jun 2013 | |
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Prof. Kelly Cosgrove's work featured in NIDA online publication, "The Science of Drug Abuse and Addiction" | May 2013 |
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Evan wins 2013 Yale Graduate Mentor Award for Natural Sciences (pics) (YouTube) (download video) (speech text) (SEAS news item) Nice GSAS news article. |
May 2013 | |
| Jenna and friends (with another friend) receive Doctoral diplomas | May 20, 2013 | Shuo Wang presents poster at BrainPET in Shanghai | May 2013 | |||
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Successful end to Spring Semester, 2013. Read what people are saying about ENAS-915 "Tracer Kinetics" |
Apr 2013 |  |
Su Jin Kim's paper on selectivity of 11C-pkab accepted for publication in J Nucl Med |
Apr 2013 | |
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Yale PET Center featured in monthly Medicine@Yale magazine. Read article here |
March 2013 | |
Jenna's paper on limitations of conventional models for describing transient dopamine events published in AJNMMI |
Jan 2013 | |
Jenna Sullivan successfully defends PhD thesis |
Dec 2012 |
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Successful end to Fall Semester, 2012. Read what people are saying about ENAS-880 (2012) | Dec 2012 | ||
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Morris Lab receives NIH grant for "Dynamic Dopamine Images: A New View of the Neurochemistry of Smoking" | Sept 2012 | Posters presented by our group at recent Neuroreceptor Mapping Meeting | Aug 2012 | ||
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Evan presents "PET Talks!" on Intro to PET Analysis to packed house (video) |
June 2012 | |
Jenna Sullivan, Su Jin Kim win Young Scientist Awards for submissions to Neuroreceptor Mapping Meeting summer 2012 in Baltimore. (Program) | May 2012 | |
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Successful end to Fall Semester, 2011. Read what people are saying about ENAS-880 (2011) | Dec 2011 |
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Sept 10: Evan completes "Closer to Free" 100 mile bike ride in 7:09:30 + rest stops. Raises $1750 for Smilow Cancer Hospital. | Sept 2011 |
Cool Images
Dopamine Multi-Movie of cigarette smoking!
Photo of Shuo Wang and friend at Chinese New Year's Gala January 2014
Lab photo from first cookout of 2013
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Evan's
Smoking Questionaire (v4) (this is correct as of 11/12/11) |
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Human Research Study Participant Advance Request (for rac_pd) |
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| How to split the Dose (xls) |
Physical Exam Forms (pdf) | ||
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Smoking Checklist |
For PET PIs (soon to be available through main Yale PET website)
| Protocol Initiation Form (trial online version - this is under development) |
sends data to prot_init.cgi |
| will send data to pet.scheduling@yale.edu | |
| Prorocol Intiation Form (trial online version 3) |
Seminar Series
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Answers to In-frequently Asked PET
Questions
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BIO
Evan D. Morris, PhD has been working in the field of PET and functional imaging for 20 years. He specializes in kinetic
modeling of dynamic image data. He was trained as a biomedical engineer
and before that as a chemical engineer. In the past, he has taught courses at
the undergraduate and graduate levels in Medical Imaging, Tracer Kinetics,
Biomedical Transport, and Biomedical Ethics, among others. For more info about
his past classroom teaching at Indiana University, Purdue University at
Indianapolis (IUPUI), including online lectures (video and Powerpoints)
for some courses, please follow the link to his IUPUI
website. Morris joined the
Dr
Morris and his students have been working on kinetic models to estimate the
dynamics of endogenous neurotransmitters from PET data. A recent publication in Neuroimage in
2010 demonstrated a novel analysis strategy for creating the first
ever “movies” of dopamine action in the living brain. The movies
can be viewed here (movie of "early"
finger-tapping, movie of "late"
finger-tapping). Altered neurotransmitter kinetics may explain the
mechanism of addiction of some drugs. This work
uses knowledge of numerical methods, biochemistry, image and signal
processing, parameter estimation, and programming. An earlier
paper in Molecular Imaging and Biology compared the
estimates of dopamine curves from fitting models to PET data to direct microdialysis measurements. A collection of papers to
result from this project can be downloaded as a zip file here. (~8Mb) The
work was funded by the Whitaker Foundation and the National Institute on
Alcohol Abuse and Alcoholism.
While
in
<>Interests
Prof. Morris is currently interested in the use of PET imaging (of people and
animals) with neuroreceptor tracers to understand and
improve treatments for Parkinson’s disease, alcoholism, smoking, drug
abuse and cancer.
Current Active Projects (all use PET imaging and some type(s) of mathematical modeling)
Is there a brain pattern of dopamine activation in the brain that represents the signature of addiction to smoking cigarettes? (To marijuana?) (To other drugs of abuse?)
Are kappa antagonists viable medications for the treatment of depression?
What is the precise molecular target of the cancer drug erlotinib that is used to treat lung cancer? Can we image the target and predict treatment outcome?
How is the pattern of dopamine activation in your brain during smoking altered by treatment?
Does stress add to the likelihood of relapse to smoking? Is dopamine the mediator of this effect?
Job Opportunities
1. Many opportunities for students to do research rotations. If you are a BME student or an INP student and need a rotation, please email Dr Morris
Past interests of Prof Morris:
Small animal imaging. A recent
paper details the design and validation of a stereotactic head-holder for
imaging two rats in a PET scanner at the same time. The paper was
published in Journal of Neuroscience Methods. Get it here.
Direct reconstruction of PET data to parametric images. This work was a collaboration with colleagues at
<>
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Course Number(s) |
Title (link to
course webpage) |
Semester |
| ENAS 915 |
Tracer Kinetics and Modeling |
Spring 2013 |
| ENAS 880 / INP 523 |
Imaging Drugs in the Brain |
Fall 2018 |
| ENAS 880 / INP 523 |
Imaging Drugs in the Brain |
Fall 2016 |
| ENAS 880 / NSCI 523 |
Imaging Drugs in the Brain |
Fall 2015 |
| ENAS 880 / NSCI 523 |
Imaging Drugs in the Brain |
Fall 2014 |
| ENAS 880 / NSCI 523 |
Imaging Drugs in the Brain |
Fall 2013 |
| ENAS 880 / NSCI 523 | Imaging Drugs in the Brain | Falll 2012 |
| ENAS 880 / NSCI 523 | Imaging Drugs in the Brain | Falll 2011 |
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ENAS 880 / NSCI 523 |
Fall 2010 |
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ENAS 503 |
Ethics and Professional Development for
Biomedical Scientists and Engineers |
Spring 2011 |
| ENAS 508 (RCR) |
Responsible Conduct of Research |
Spring 2016 |
| ENAS 508 (RCR) |
Responsible Conduct of Research |
Spring 2017 |
| ENAS 508 (RCR) |
Responsible Conduct of Research |
Spring 2018 |
| ENAS 508 (RCR) |
Responsible Conduct of Research |
Spring 2019 |
| Old lectures |
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| Perfusion MR |
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| Julia and Sujin take a ride along the Farmington canal and find the perfect sign (blue). |
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| Riders before an Aug 2011 training ride to prepare for Closer to Free ride |
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| With Stuart Basseches... somewhere along the Hudson River... on a hot-as-hell ride , July 2011. (100 mi) |
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| Evan and Bob ride from UConn (Storrs, CT) to Welleseley College (Wellesely, MA) June 2012 (100 mi) |
Conference in New Orleans, SNM, June 2008
photo grid
Lecture in Turku, Turku PET symposium, June 2008
photo grid (Turku)
photo grid (Talin,
Estonia)
Lecture in Copenhagen METPETS consortium, June 2009
photo grid
photo grid 2
(commuting in Copenhagen)
Lecture in Chicago, BrainPET, 2009
photo grid
Lecture at Univ Washington, Seattle, June 2010
photo grid - Seattle
photo grid -
Victoria, BC
Lecture at Univ Glasgow, July 2010
photo grid
Lecture at Bogazici University (Biomedical
Institute), Istanbul, Nov 2010
Photos
Lecture at Hadassah Hospital, Jerusalem, Nov 2010
Photos
Lecture at Univ Wisconsin, Madison, Nov 2010
Photos
Lecture at Mass General Hospital, Boston, Dec 2010
BS, BS (Chemical Engineering, Biology) MIT
MS, PhD, (Biomedical Engineering)
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