Home Page of Evan D. Morris, PhD
Indiana University, Purdue University, Indianapolis (IUPUI)

                                                                                                                                       

Research Interests: Application of modeling and parameter estimation to dynamic PET (and MR and CT) data in order to investigate interesting and challenging neurochemical questions of mechanism and etiology of neuropsychiatric diseases.

Funding Sources

• Grant RG 02-0126 awarded by Whitaker Foundation to E Morris (9/02 - 8/05)

• Grant TF 04-0034  awarded by Whitaker Foundation to E Morris (9/05 - 8/06  --- extended to 12/06)

• NIH (NIAAA) (PI -E. Morris)  Temporal Response of Dopamine to Alcohol Imaged via PET

• NIH (NCI) (PI- Ray Muzic, Case Western Reserve University)

• NIH (PI - D. Kareken, co-I E Morris)  Pilot project funded through the  Indiana Alcohol Research Center

• NIH (PI - E. Morris, co-I K. Yoder)    Pilot project funded through the  Indiana Alcohol Research Center

Current Projects

• Model-based characterization of temporal changes in endogenous neurotranmitters noninvasively with PET (with M Normadin, K Yoder)

• Model-independent (i.e., nonparametric) of temporal changes in endogenous neurotranmitters noninvasively with PET characterization (C Constantinescu and C Bouman)

• Perfusion and diffusion-weighted imaging of stroke and MR (with J James, K Yoder, PhD, A Bruno, MD, O Osuntukun, MD) - this is also a collaboration with MedicalNumerics, Sterling VA.

• Study of drug and alcohol craving in humans (with D Kareken, PhD, K Yoder)

• Studying neurochemical responses to alcohol in Preferring (P) and Non-preferring (NP) rats (with K Yoder, M Normandin, J Froehlich, PhD, and a cast of 1000s)

• Modeling the dopaminergic response to drugs and alcohol in disease (with K Yoder, PhD)

• Direct estimation of Parametric Images from Sinograms (C Bouman, PhD of Purdue U ,M Kamasak of Istanbul Technical U, B Christian of U of Wisconsin-Madison)

• Simulation/retrospective studies to predict the behavior of PET tracers in the presence of endogenous competitors (with K Yoder, PhD)

• Simulation studies to uderstand change in binding potential as an index of dopamine release (with K Yoder, PhD)

• Optimization of experimental PET protocols for detecting and characterizing dopamine response to stimuli (M Normandin)

• Ongoing Modeling collaborations (with R Muzic at Case Western Reserve U and B Christian, PhD at U Wisconsin-Madison)

• Rapid parameteric images for evaluation of PET tracer kinetics (with C Constantinescu)

Teaching

        
Lab members
        
         Jenna Sullivan, BS                           Graduate Student (Purdue) in Biomedical Engineering

• Accepted into PhD program in BME at Yale for 2009
• Abstract accepted to RSA 2009 (awarded RSA travel fellowship)
  
• Abstract accepted to SNM 2009
• Abstract accepted to BrainPET 2009
• Absract accepted to Soc Nucl Med meeting 2008
• Poster presented at Indiana Neuroimaging Symposium 2008
  

Emeritus Members 

• Kaitlin Tulloh and Joel Phelps Undergrads (IUPUI) in BME and ECE

• Awarded MURI fellowships for Spring 2007 to work with us and Prof Paul Salama on a PET simulator
  
  
            Marc Normandin, BS, PhD                   Graduated from Purdue in Biomedical Engineering, 2008
  

• paper submitted

• successfully defended MS thesistesting rat holder in microPET at Madison-Wisconsin 
• co-author on ACER paper 2007 
• poster on dual rat-holder presented at SNM 2007 in DC
• co-author on paper at ISBI 2006

• paper in May 2005 issue of TMI
• PhD defended!
• returned to Turkey to accept faculty position at Istanbul Technical University.
• awarded GSK Young Investigator Bursary to attend NRM 06 in Copenhagen

• Judy James, MS, PhD                           Graduated from IUPUI with MS in Biomedical Engineering
• Graduated from Purdue in Health Physics (2009)
  
• paper accepted to Comp Biol & Med!
• Segmentation software to be distributed in future release of MEDx (3.5 for UNIX and OS X)! 
• 
  

• Karmen Yoder, PhD                    Asst. Professor in Radiology
  

• • paper on Dopamine in rest condition published in Neurosci Letters
  • paper on Heterogeneous Brain Responses to Alcohol, published in ACER - now online
    
  • invited to speak at alcohol and imaging symposium at RSA 2007!
  • presentations at Neuroscience 2006
  • invited talk at RSA 2006
  • paper  in June 2005 issue of Alc Clin Exp Res !
  • poster presented at SNM 2005
  • poster presented at RSA 2005

  ChunzhiWang, MS                       Scientific Programmer

• abandoned academic life for Industry after 3 years - farewell.

• 
  

(Emeritus) Associate Members

• Sarah Berg, BS                              Graduate Student (IUSOM) in Medical Neurobiology

• working on perfecting surgery techniques for iv injections during PET 2007

• Now working with Dr Andy Chambers bit will collaborate with us.

• did a lab rotation in PET and fMRI, Spring 2006.

Presentations at Recent Conferences  (htm best viewed - sorry - with Microsoft IE)

Invited talk at XI Turku PET Symposium
Turku, Finland; May 2008
    Morris: "ntPET: Temporal Characterization of Neurotransmitter Release"

    To see a few pictures of my side-trip to Tallinn in Estonia,
click on amber chess set, below.: 

Society of Nuclear Medicine, Washington DC, June 2007

Evening outing with Brad Christian's group from Madison.

Neuroreceptor Mapping, Copenhagen, July 2006
   Direct reconstruction poster co-authors
(click on picture for more pictures)

    Kamasak      Morris     Bouman      Christian

• Morris and Yoder

Society of Nuclear Medicine, Toronto, June 2005

• Normandin et al.

Society of Nuclear Medicine, N. Orleans, June 2003

• Yoder, Wang and Morris

• Constantinescu and Morris

• Morris, Wang and Muzic

                Evan with the Sharkman at SNM 2003

BrainPET03, Calgary, July 2003

• Morris, Wang and Muzic

click on us to see more examples of our work...

Frequently Used Links

:

CLASS LECTURES ON MEDICAL IMAGING - video and slides available at these links
Medical Imaging Applications Spring 2005	Check the homework,  lectures Spring 2002	Medical Imaging  Course, Spring 2003	click on image to access BME senior design page
	Other links for use of lab members and general scientific community:
Check the latest paper		Sean O'Connor's Alcohol meeting	THE RATRIX
Find a faculty member in Radiology	Apply for $$$  to do a Pilot Imaging study	Find a friend at IUPUI	Ray Muzic's COMKAT website We use the COMKAT library of compartmental modeling fucntions to develop our modeling software in Matlab quickly and efficiently.
Rat vs. Rat	Check your IUPUI        or                    Yale Mail	Upcoming events	Mike Miller's IndyPET info IndyPET images IndyPET Tumor Slide
Check out our new  Model Package screenshots	Modeling Package FAQ	Schedules       Schedule of rat scans etc	Modeling Tutorial Get Started with the Package
status  -->> Computer FAQs for Evan's lab	Contact Lists	Radiology and Imaging Sciences Phone List  emergencies: full list - requires password	Paper Discussion at Monday Lab Group
L     E     C     T      U     R     E     S	L     E     C     T      U     R     E     S	L     E     C     T      U     R     E     S
"Imaging Neurotransmission and Other Cool Stuff" - Talk to BME dept., Purude, Oct 18, 2002	Press Figure for Evan's recent PET Talk delivered at Center for BME, UKY Mar '02	Press Figure for Evan's recent talk to Institute for Psychiatric Research at IU School of Med, May '02	Evan's Lab Click Here
Cristian's results	Latest paper from our group - published in Molecular Imaging  2005	Brad and Charlie, click here.	Imaging Sciences Division Research Update Calendar of Talks
Introductory fMRI lecture(s) for Experimental Methods class                           Lecture 1             Lecture 2	Introduction to PET analysis -- curve fitting. How does PET differ from fMRI?	What is Direct reconstruction ? Click here.	What is ntPET? Click here.
Biomedical Mass Transport and Modeling Spring 2006	What have piggy banks and pink quarters got to do with tracer kinetics? (Click on pink quarter to find out.) An introductory talk on intravascular tracers, freely diffusable tracers and the ideas behind tracer kinetic models Second part, click here.	Tracer Kinetics and Dynamic Data Analysis Fall 2006

Topics of interest:

Introduction to PET modeling
Dynamic PET modeling
Combining PET and microdialysis
Small animal scanners - quantitation
Dynamic MR modeling
Common ways to use PET imaging of neuroreceptors
Modeling software
Modeling review
Papers to read
 
 

Other Useful links

Color-coded Key to Links:

Modeling Software COMKAT

        - developed by Ray Muzic, PhD at Case Western Reserve University -
we use this software in our lab for simulating and fitting compartmental models to dynamic PET data.

Modeling Review Material

1.

"Modeling of  Receptor Images in PET and  SPECT",  Morris, Muzic, Christian, Endres and Fisher, 
appears in M. Ernst and J Rumsey eds., Functional Neuroimaging in Child Psychiatry, Cambridge University Press (2000).

2."Kinetic Modeling in PET"   Morris, Endres, Schmidt, Christian, Muzic and Fisher. in  Emission Tomography , Wernick and Aarsvold eds., Academic

                    Evan's Free Speech Area  (aka Evan's 'blog)

FAMILY PICTURES FROM TRIPS AND OTHER EVENTS (2000-2005)
Family Pictures from 2000...
Dancer
Heart Glasses
Artist
Packing

2001
Pictures of Elana and Jackie  - August, 2001
Picture of the whole family - September, 2001
Lobster Tale - Nov. 2001

Spring 2002...
Birthday Candles
Gymnastics 

Spring 2003...
Family at the Grand Canyon
1   2   3   4   5   6   7  8 

Back to School 2003

Family trip to Sanibel Island Summer 2004

Back to School 2004

Jackie sings with Indianapolis Children's Choir

Adventures in 2005

Elana does Purim2005 - Indian style

Kindergarten Graduate and Mom - Jun 2005

Jackie and fans after 2005 Dance recital

Elana on Father's day 2005

Jackie on Father's day 2005

A few sample pics from Israel trip, summer 2005

       Days 1-2 of Israel trip (Jerusalem)
       Days 3-5 of Israel trip (Jerusalem - Tel Aviv)
           Day 4 - The main event
       Day 5 - Outside Cesaria, Zichron Yaakov
       Day 6 - The Golan
       Day 6 - More of the Golan and extreme sports

       Day 6-7 Extreme Sports, Dude Ranch, Negev, Dead Sea Views
       Day 8 Masada
       Day 9 Ramon Crater in the Negev
       Day 9 More Ramon Crater, Eilat Stones

       Evan's angels show off in Kfar Blum
       Jackie's pictures of Massada

Jackie discusses Boradway Camp in Indy Star

2006

Family trip to California for Soc Nuc Med meeting 2006

Pictures from trip to Copenhagen for NRM 06 (hi-res version; lo-res version) and Oxford (hi-res version;  lo-res version)

  SEE MY (Elana's) LATEST ARTWORK

Elana's award-winning drawing that appeared on Cheryl Nelson's AccuWeatherChannel contest site
(for larger version, click here)

last updated: 4:30 pm Sept 3, 2007 (EDM)

back to top of page