January 12, Thursday (2:15-5:30 pm) at TAC Auditorium
(300 Cedar Street)
2012 Robert G. Shulman Lectures in Magnetic Resonance
Symposium on “Imaging Brain Function with
Magnetic Resonance: The Next 20 Years”
"fMRI: Present and Future"
Seiji Ogawa, Ph.D. (Tohoku Fukushi University)
"Frontiers in Functional Neuroimaging: From
Cortical Columns to Whole Brain Functional Dynamics"
Kamil Ugurbil, Ph.D.
(University of Minnesota)
"Functional Network Organization of the Brain as Revealed by fMRI"
R. Todd Constable, Ph.D. (Yale University)
"Brain Energetics and Neuronal Activity: Can fMRI Provide Quantitative Neuronal Activity Maps?"
D. S. Fahmeed Hyder, Ph.D.
(Yale University)
"Brain Energy and Consciousness"
Robert G. Shulman, Ph.D. (Yale University)
February 21, Tuesday (4:15 pm) at N135 TAC (300 Cedar Street)
"Direct Assessment of the Temporal Resolution of the Olfactory System
via an Optogenetic Smell Paradigm: "Odor
Image" or "Odor Movie"?"
Justus Verhagen (John B. Pierce Foundation, New Haven,
CT)
It has long been established that the
olfactory system maps the high-dimensional odor space onto the 2 spatial
dimensions of the glomerular layer of the olfactory
bulb. Recent experiments have suggested that the temporal dynamics of the glomerular responses may also encode information about
odorants. In the talk I will present our behavioral paradigm and new data that
directly addresses whether this third (temporal) coding dimension can be used
by the olfactory system of awake channelrhodopsin
mice.
March 13, Tuesday (4:15 pm) at N135 TAC (
"Dendrimer-Based Smart Contrast Agents for
Targeted Molecular Imaging"
Meser Ali (Henry Ford Health System,
Dendrimers have well-organized high branches with a layered
architecture providing a series of versatile chemical modification for various
purposes. Consequently, this dendrimer
nanotechnology explores a new promising class of nanoscale
carriers for therapeutic drugs and imaging agents using passive and active
targeting approaches. The pH difference between normal and tumor tissues
provides an opportunity for development of novel diagnostic and therapeutic
agents specifically targeting cancer cells. Recently, the pH-selective
insertion and folding of pH low insertion peptide (pHLIP)
in membranes has been demonstrated to target acidic tissue in vivo, including
solid tumors. A pH responsive dendrtric MRI
contrast agent containing pHLIP has been developed to
sense pH and target the acidic microenvirnment of
tumors. In vivo application of tumor targeted dendrimeric
MRI contrast agents will be presented.
March 20, Tuesday (4:15 pm) at N135 TAC (300 Cedar Street)*
"High Resolution MRI of the Retina in Animal Models and Humans"
Timothy Duong (Research Imaging Center, UT San Antonio, TX)
This talk summarizes the brief history of
development and application of lamina-specific anatomical, physiological and
functional MRI to study the normal and diseased retinas. MRI reveals multiple
anatomical layers within the retina, the retinal and choroid vascular layers,
and the unique differential regulations of hemodynamics
of the two vascular layers. The key advantages of MRI are it is non-invasive,
has depth resolution and it offers multimodal (structural, physiological and
functional) information. The key disadvantages of MRI are it has higher cost
and lower spatiotemporal resolution which makes it more susceptible to eye
movement in awake subjects relative to optical imaging
techniques to date. MRI application to the retina is still in its infancy. It
will likely to have increasing applications in animal models of retinal
diseases. This approach has been extended to humans. There are many remaining
challenges and along comes with exciting opportunities for new development and
discovery.
April 10, Tuesday (4:15 pm) at N135 TAC (
"Neuroimaging Consciousness and Anesthesia"
Michael Alkire (Anesthesiology, UC
Anesthesia offers an important tool for the
scientific study of consciousness. Recent works will be discussed with an aim
towards answering basic questions regarding the nature of consciousness and how
it is removed by anesthesia. What brain areas and systems must be turned
off to remove consciousness? What brain regions or key processes must be
turned back on to restore consciousness? What brain regions might be critical
for the amnesic effect of anesthesia? This lecture will touch upon these key
topics in order to provide the background needed for understanding future
developments in anesthesia research.
*co-sponsored by the Neuroimaging Sciences
Training Program
Refreshments served 15 minutes prior to start of seminar.
Please call 5-6199 / 5-6622 for directions.