January 12, Thursday (2:15-5:30 pm) at TAC Auditorium (300 Cedar Street)
2012 Robert G. Shulman Lectures in Magnetic Resonance
Symposium on “Imaging Brain Function with Magnetic Resonance: The Next 20 Years”
"fMRI: Present and Future"
Seiji Ogawa, Ph.D. (Tohoku Fukushi University)
"Frontiers in Functional Neuroimaging: From Cortical Columns to Whole Brain Functional Dynamics"
Kamil Ugurbil, Ph.D. (University of Minnesota)
"Functional Network Organization of the Brain as Revealed by fMRI"
R. Todd Constable, Ph.D. (Yale University)
"Brain Energetics and Neuronal Activity: Can fMRI Provide Quantitative Neuronal Activity Maps?"
D. S. Fahmeed Hyder, Ph.D. (Yale University)
"Brain Energy and Consciousness"
Robert G. Shulman, Ph.D. (Yale University)

February 21, Tuesday (4:15 pm) at N135 TAC (300 Cedar Street)

"Direct Assessment of the Temporal Resolution of the Olfactory System via an Optogenetic Smell Paradigm: "Odor Image" or "Odor Movie"?"
Justus Verhagen (John B. Pierce Foundation, New Haven, CT)
It has long been established that the olfactory system maps the high-dimensional odor space onto the 2 spatial dimensions of the glomerular layer of the olfactory bulb. Recent experiments have suggested that the temporal dynamics of the glomerular responses may also encode information about odorants. In the talk I will present our behavioral paradigm and new data that directly addresses whether this third (temporal) coding dimension can be used by the olfactory system of awake channelrhodopsin mice.

March 13, Tuesday (4:15 pm) at N135 TAC (300 Cedar Street)
"Dendrimer-Based Smart Contrast Agents for Targeted Molecular Imaging"
Meser Ali (Henry Ford Health System, Detroit, MI)

Dendrimers have well-organized high branches with a layered architecture providing a series of versatile chemical modification for various purposes.  Consequently, this dendrimer nanotechnology explores a new promising class of nanoscale carriers for therapeutic drugs and imaging agents using passive and active targeting approaches.  The pH difference between normal and tumor tissues provides an opportunity for development of novel diagnostic and therapeutic agents specifically targeting cancer cells.  Recently, the pH-selective insertion and folding of pH low insertion peptide (pHLIP) in membranes has been demonstrated to target acidic tissue in vivo, including solid tumors.  A pH responsive dendrtric MRI contrast agent containing pHLIP has been developed to sense pH and target the acidic microenvirnment of tumors.  In vivo application of tumor targeted dendrimeric MRI contrast agents will be presented.

March 20, Tuesday (4:15 pm) at N135 TAC (300 Cedar Street)*
"High Resolution MRI of the Retina in Animal Models and Humans"
Timothy Duong (Research Imaging Center, UT San Antonio, TX)

This talk summarizes the brief history of development and application of lamina-specific anatomical, physiological and functional MRI to study the normal and diseased retinas. MRI reveals multiple anatomical layers within the retina, the retinal and choroid vascular layers, and the unique differential regulations of hemodynamics of the two vascular layers. The key advantages of MRI are it is non-invasive, has depth resolution and it offers multimodal (structural, physiological and functional) information. The key disadvantages of MRI are it has higher cost and lower spatiotemporal resolution which makes it more susceptible to eye movement in awake subjects relative to optical imaging techniques to date. MRI application to the retina is still in its infancy. It will likely to have increasing applications in animal models of retinal diseases. This approach has been extended to humans. There are many remaining challenges and along comes with exciting opportunities for new development and discovery.

April 10, Tuesday (4:15 pm) at N135 TAC (300 Cedar Street)*
"Neuroimaging Consciousness and Anesthesia"
Michael Alkire (Anesthesiology, UC Irvine, CA)

Anesthesia offers an important tool for the scientific study of consciousness. Recent works will be discussed with an aim towards answering basic questions regarding the nature of consciousness and how it is removed by anesthesia.  What brain areas and systems must be turned off to remove consciousness?  What brain regions or key processes must be turned back on to restore consciousness? What brain regions might be critical for the amnesic effect of anesthesia? This lecture will touch upon these key topics in order to provide the background needed for understanding future developments in anesthesia research.

*co-sponsored by the Neuroimaging Sciences Training Program

Refreshments served 15 minutes prior to start of seminar.

Please call 5-6199 / 5-6622 for directions.