| Imaging Drugs in the Brain --- Fall 2011
Syllabus --- ENAS 880 / NSCI 532 ----
Yale University |
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back
to class home page |
back to Evan's home page |
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Lecture (L): |
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Methodology paper (MP): |
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key: |
Application paper (AP): |
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Other reading material (OR): |
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date |
class # |
Paper type |
Topic |
Author |
Journal |
Year |
Pages |
Extra |
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(room) |
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| Tues |
6-Sep |
1 |
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Overview, course organization,
expectaions |
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Lecture pieces |
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1. intro |
Simple Intro to
PET |
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| (Morris) |
(N209) |
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2. what can we image? |
Nonspecificity
of PET demands modeling |
<-- (right click to
download ppt file) |
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3. functional imaging |
Imaging Drugs - A Preview |
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Good overview paper to read
before coming to first class: |
Imaging
the Addicted Brain |
Fowler et al. |
Science & Practice
Perspectives |
2007 |
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| Tues |
13-Sep |
2 |
(L): |
Receptors/receptor tracers/kinetic
models |
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A
Quantitative Model for the In Vivo Assessment of Drug Binding Sites with
Positron Emission Tomography |
Mintun et al. |
Ann Neurol |
1984 |
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| (Morris) |
(N209) |
papers to be discussed this week
--> |
(AP): |
Imaging
Dopamine Receptors in the Human Brain by Positron Tomography. |
Wagner et
al |
Science |
1983 |
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(OR): |
Quantitative
analysis of D2 dopamine receptor binding in the living human brain by PET |
Farde L, Hall H, Ehrin E, et al |
Science |
1986 |
231: 258-61 |
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| Tues |
20-Sep |
3 |
(L): |
Displacement of tracers by
neurotransmitters (notes) |
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Simulations,
sensitivity, (2011 notes) |
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Effects
of endogenous dopamine on measures of [18F]N-methylspiroperidol binding in
the basal ganglia: Comparison of simulations and experimental results from
PET studies in baboons. |
Logan et
al |
Synapse |
1993 |
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| (Morris) |
(N209) |
papers to be discussed this week
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(AP): |
Evidence
for Striatal Dopamine Release During a Video Game |
Koepp et al, |
Nature |
1998 |
vol 393 |
learn
more: Lappin et al 2009 |
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(OR): |
In vivo
imaging of neuromodulation using PET: Optimal ligand characteristics and task
length for detection of activation |
Morris et al, |
Human Brain Mapping |
1995 |
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| Tues |
27-Sep |
4 |
(L): |
Intro to Equilibrium Kinetics:
Bolus vs Bolus/Infusion |
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Nicotine-induced
dopamine release in primates measured with [11C]raclopride PET. |
Marenco et al |
Neuro-psychopharm |
2004 |
29(2):259-68 |
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(N209) |
papers to be discussed this week
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(MP): |
PET
physiological measurements using constant infusion. |
Carson |
Nuc Med Biol |
2000 |
657-60 |
learn more: Carson et
al 1993 |
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(OR): |
Measurement
of dopamine release with continuous infusion of [11C]raclopride: optimization
and signal-to-noise considerations |
Watabe |
J Nucl Med |
2000 |
Mar;41(3):522-30 |
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Review article |
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| Tues |
4-Oct |
5 |
(L): |
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topic: . |
Studies of
Alcohol drinking |
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possibly some tidbits here - not
overly relevant but perhaps a good introductory article |
(MP): |
Positron
emission tomography--a tool for identifying the effects of alcohol dependence
on the brain. |
Wong et al |
Alcohol Res Health |
2003 |
27(2):161-73 |
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Sex
Differences in Striatal Dopamine Release in Young Adults After Oral Alcohol
Challenge: A Positron Emission Tomography Imaging Study With [11C]Raclopride |
Urban et al |
Biol Psychiatry |
2010 |
689-96 |
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(N209) |
these 3 papers are
similar - lets compare designs |
(AP): |
When
What You See Isn’t What You Get: Alcohol Cues, Alcohol Administration,
Prediction Error, and Human Striatal Dopamine |
Yoder et al |
ACER |
2009 |
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and results re dopamine |
(AP): |
Alcohol
promotes dopamine release in the human nucleus accumbens. |
Boileau |
Synapse |
2003 |
49(4):226-31. |
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Good short review: PET concepts
& alcohol research |
Review article |
Assessing
Dopaminergic Neurotransmission with PET: Basic Theory and Applications in
Alcohol Research |
Yoder et al |
Curr Opinions |
2011 |
7,118-124 |
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| Tues |
11-Oct |
6 |
topic: . |
Animal
models of addiction |
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this paper is referred to by the
latter LeFoll paper: --> |
(MP): |
Validation
of an Extracerebral Reference Region Approach for the Quantification of Brain
Nicotinic Acetylcholine Receptors in Squirrel Monkeys with PET and
2-18F-Fluoro-A-85380 |
LeFoll et al |
J Nucl Med |
2007 |
48:1492–1500 |
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| (Cosgrove
& friend) |
(N209) |
papers to be discussed this week
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Social dominance in monkeys:
dopamine D2 receptors and cocaine self-administration |
Morgan et al |
Nature Neurosci |
2002 |
5(2) 169:174 |
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(OR): |
Baseline Expression of a4b2*
Nicotinic Acetylcholine Receptors Predicts Motivation to Self-administer
nicotine |
LeFoll et al |
Biol Psychiatry |
2009 |
65:714-716 |
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Review article |
PET Imaging of Dopamine D2
Receptors in Monkey Models of Cocaine Abuse:Genetic Predisposition Versus
Environmental Modulation |
Nader and Czoty |
Am J Psychiatry |
2005 |
162:1473-1482 |
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| Tues |
18-Oct |
7 |
topic: . |
Imaging
studies of Smoking |
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Attenuation
correction |
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(MP): |
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(AP): |
beta2-Nicotinic
acetylcholine receptor availability during acute and prolonged abstinence
from tobacco smoking. |
Cosgrove et al |
Arch Gen Psychiatry |
2009 |
Jun;66(6):666-76 |
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Smoking-induced
ventral striatum dopamine release. |
Brody et al |
Am J Psychiatry |
2004 |
Jul;161(7):1211-8. |
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(N209) |
these 3 papers are similar - lets
compare designs and results re DA |
(AP): |
The
hedonic response to cigarette smoking is proportional to dopamine release in
the human striatum as measured by positron emission tomography and
[11C]raclopride. |
Barret et al |
Synapse |
2004 |
Nov;54(2):65-71. |
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(AP): |
Smoking
Modulation of mu-Opioid and Dopamine D2 Receptor-Mediated Neurotransmission
in Humans |
Scott |
Neuropsychopharm |
2007 |
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chewing nicotine gum |
learn more: |
Enhanced dopamine release by nicotine in cigarette smokers: a
double-blind, randomized, placebo-controlled pilot study |
Takahashi |
Int J Neuropsychopharm |
2008 |
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nicotine nasal spray |
learn more: |
The Effect of Nicotine on Striatal Dopamine Release in Man: A
11C-raclopride PET Study |
Montgomery |
Synapse |
2007 |
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(OR): |
Pharmacology of nicotine:
addiction, smoking-induced disease, and therapeutics. |
Benowitz NL. |
Annu Rev Pharmacol Toxicol |
2009 |
49:57-71 |
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another review |
In
vivo brain imaging of human exposure to nicotine and tobacco |
Sharma and Brody |
in NIC PHARM |
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| Tues |
25-Oct |
8 |
topic: . |
Imaging
Serotonin and Tryptophan depletion |
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(OR): |
Effects of endogenous
neurotransmitters on the in vivo binding of dopamine and 5-HT radiotracers in
mice |
Rice |
Neuropsychopharm |
2001 |
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Comparison of
[18F]altanserin for PET inaging of serotonin (2A) reeptors in baboon brain:
pharmacological studies |
Staley |
Nucl Med Biol |
2001 |
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| (Williams
and friend) |
(N209) |
papers to be discussed this week
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(AP): |
5-HT(1A) receptor imaging in the
human brain: effect of tryptophan depletion and infusion on [(18)F]MPPF
binding |
Udo de Haes |
Synapse |
2002 |
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(AP): |
Effects of reduced
endogenous 5-HT on the in vivo binding of the serotonin transporter
radiolaigand 11C-DASB in healthy humans |
Talbot |
Synapse |
2005 |
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finally... someone images serotonin release with PET !! |
learn more: . |
Fenfluramine-induced
serotonin release decreases [11C]AZ10419369 binding to 5-HT1B-receptors in
the primate brain |
Finnema |
Synapse |
2010 |
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| Tues |
1-Nov |
9 |
topic: . |
Nicotine, Smoking, SPECT, imaging nicotinic
receptors |
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Lassen Plots, Vnd |
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beta2-Nicotinic
acetylcholine receptor availability during acute and prolonged abstinence
from tobacco smoking. |
Cosgrove et al |
Arch Gen Psychiatry |
2009 |
Jun;66(6):666-76 |
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and friend) |
(N209) |
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(AP): |
Quantification
of Smoking-Induced Occupancy of β2-Nicotinic Acetylcholine Receptors:
Estimation of Nondisplaceable Binding |
Esterlis et al |
J Nucl Med |
2010 |
(51), 1226-1233 |
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(AP): |
Brain nicotinic
acetylcholine receptor occupancy: effect of smoking a denicotinized
cigarette. |
Brody et al |
Int J Neuropsychopharm |
2008 |
305-316 |
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| Tues |
8-Nov |
10 |
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Modeling
Neurocircuitry with PET: Role of Dopamine in Cocaine Abuse |
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Review: |
Imaging
dopamine’s role in drug abuse and addiction |
Volkow et al |
Neuropharmacology |
2009 |
56(Suppl 1): 3–8 |
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Elevated
Striatal Dopamine Transporters During Acute Cocaine Abstinence as Measured by
[123I]b-CIT SPECT |
Malison et al |
Am J Psychiatry |
1998 |
155:832:834 |
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| (Williams
and friend) |
(N209) |
papers to be discussed this week
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(AP): |
Amphetamine-induced
dopamine release: markedly blunted in cocaine dependence and predictive of
the choice to self-administer cocaine. |
Martinez D,et al. |
Am J Psychiatry |
2007 |
Apr;164(4):622-9. |
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(OR): |
Increased
Occupancy of Dopamine Receptors in Human Striatum during Cue-Elicited Cocaine
Craving |
Wong et al |
Neuropsychopharmacology |
2006 |
31, 2716–2727 |
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Introduction
to Alcoholism - and predictors of alcoholism |
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| Tues |
15-Nov |
11 |
topic: |
PET studies of drug
occupancy: how does naltrexone work in alcoholics? Kappa?, mu?, delta? |
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Key Background |
Family history of Alcoholism influences naltrexone-induced
reduction in alcohol drinking |
Krishnan-Sarin et al |
Biol Psychiatry |
2007 |
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(N205) note different room |
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AP |
Differences in delta- and mu-opioid receptor blockade measured
by PET in naltrexone-treated recently abstinent alcohol-dependent
subjects |
Weerts et al |
Neuropsychopharm |
2008 |
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MP |
11C-GR103545,
a radiotracer for imaging K-opioid receptors in vivo with PET: synthesis and
evaluation in baboons |
Talbot et al |
J Nucl Med |
2005 |
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| Tues |
22-Nov |
B
R E A
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dream about PET imaging while sleeping off the turkey! |
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| Tues |
29-Nov |
12 |
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PET vs fMRI analysis and papers - on Obesity |
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fMRI
basics... comparison to PET? |
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Excerpts from "Handbook of
Functional MRI Data Analysis" and other texts |
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PET:.. |
Brain
dopamine and obesity |
Wang et al |
Lancet |
2001 |
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| (Morris
and friends) |
(N205) note different room |
papers to be
discussed this week --> |
fMRI:.. |
Relation Between Obesity and
Blunted Striatal Response to Food Is Moderated by TaqIA A1 Allele |
Stice et al |
Science |
2008 |
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fMRI vs PET: |
Imaging human reward
processing with positron emission tomography and functional magnetic
resonance imaging |
Urban et al |
Psychopharmacology |
2011 |
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(learn more) Review:.. |
Similarity
Between Obesity and Drug Addiction as Assessed by Neurofunctional Imaging |
Wang et al |
J Addict Disease |
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(learn more) Review:.. |
Neuroimaging
and obesity: current knowledge and future directions |
Carnell et al |
Obesity reviews |
2011 |
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