Difference between revisions of "BME faculty Senior Projects List 2014"
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Revision as of 03:30, 18 January 2014
BME Faculty List of Possible Undergraduate Research Projects
Note to students. The projects listed in this matrix represent possible projects available to BME undergraduate students. We encourage you to contact listing faculty members for further information.
First |
Last (link to website) |
Lab Description | Track | Location | Project title | Project title | Project title | Project title |
---|---|---|---|---|---|---|---|---|
Jay | Humphrey | Vascular Mechanics and Mechanobiology Lab | Biomechanics | Malone | Quantitative Histology | Computational Hemodynamics | Mechanobiological Assessments using Cell / Tissue Culture | Computer-aided Experimentation |
Evan | Morris | Neuroimaging of Addiction and Medications Development | Imaging | PET Center | Imaging the Brain's Dopamine Response to Smoking Cigarettes | Imaging the action of a Medication for Alcoholism. | Build a Mock PET Scanner | |
Jim | Duncan | Imaging | TAC |
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Rich | Carson | Imaging | PET Center |
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Mark |
Saltzman | Malone |
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Chi |
Liu |
Imaging |
PET Center |
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Todd |
Constable |
Imaging | TAC |
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Larry |
Staib |
Imaging | TAC |
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Hemant | Tagare | Imaging | TAC |
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Angelica | Gonzalez | Malone |
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Andre | Levchenko | West Campus |
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Stuart | Campbell | Biomechanics | Malone |
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Fahmeed | Hyder | Functional and Molecular Imaging of the Brain | Imaging |
TAC |
Calibrated fMRI for basal metabolism |
Quantitative metabolic PET | Liposomal BIRDS | Dendrimeric BIRDS |
Rong | Fan | Single-cell analysis for cancer research and immunology | All tracks | Malone Engineering Center | Single-cell analysis of T cell response | Genome editing and cancer development | MicroPhysiological Systems | High-content imaging for systems biology |
zFirst | zLast | Lab Name | Track | Location | First Project Name | Second Project Name | Third Project Name | Fourth Project Name |
zFirst | zLast | Lab Name | Track | Location | First Project Name | Second Project Name | Third Project Name | Fourth Project Name |
zFirst | zLast | Lab Name | Track | Location | First Project Name | Second Project Name | Third Project Name | Fourth Project Name |
zFirst | zLast | Lab Name | Track | Location | First Project Name | Second Project Name | Third Project Name | Fourth Project Name |
zFirst | zLast | Lab Name | Track | Location | First Project Name | Second Project Name | Third Project Name | Fourth Project Name |
Lab Descriptions
Vascular_Mechanics_and_Mechanobiology_Lab
(Biomechanics Track) Our focus is on (i) developing computational models for understanding vascular disease progression and designing clinical interventions, (ii) using genetic, pharmacologic, and surgical models to elucidate mechanisms that underlie diverse vascular conditions, and (iii) using tissue engineered constructs to test hypotheses of mechanosensing and mechanoregulation of extracellular matrix.
Functional_and_Molecular_Imaging_of_the_Brain
(Bioimaging Track) The societal burden of misdiagnosed brain disorders and diseases is substantial. The Hyder lab is leading breakthroughs in quantitative and translational imaging technologies, based primarily on magnetic resonance methods, to visualize molecular processes of function and dysfunction at the laminar level.
A primary interest of the Hyder lab is to develop functional imaging techniques that relate neural activity to underlying laminar structure in health and disease. Emphasis is on fMRI, but other multi-modal fMRI methods in conjunction with MRS, electrophysiology, optical imaging, and PET are being sought for increased biomarker specificity. Specific areas of interest include (i) understanding the role of the extraordinarily high energy demands of ongoing and intrinsic activity within neural populations as potential for quantitative disease biomarker, (ii) advancing the spatiotemporal resolution of functional imaging to understand the relation of cellular metabolism in health and disease (e.g., healthy aging, Alzheimer’s disease, depression, epilepsy, schizophrenia), and (iii) developing advanced calibrated fMRI methods for using oxidative energy as an absolute index of neural activity, both with task and rest paradigms, across cortical and subcortical regions.
Another active interest in the Hyder lab is molecular imaging with magnetic resonance technologies where several disciplines connect, from chemistry and physics to material science and physiology. A new molecular imaging method, pioneered in the Hyder lab called BIRDS, combines high MRI spatial resolution with high MRS molecular specificity. The method, quite unconventionally, detects the paramagnetically-shifted and non-exchangeable protons from lanthanide (or transition) metal ion probes for high spatiotemporal resolution biosensing. Highly precise molecular imaging of temperature and pH is achievable with BIRDS. Current areas of relevance are (i) design of new molecular probes for BIRDS, (ii) early cancer detection and metastasis using absolute pH imaging, (iii) application of new probes for BIRDS as molecular targets for diseases (e.g., diabetes), and (iv) detection of tumor response to treatments (e.g., radiation, chemotherapy, heat).
Lab_Name
Your text about your lab goes in a paragraph like this.
Project Descriptions
Quantitative_Histology
We use histology and immunohistology to quantify regional variations in the distributions of vascular cell phenotype, extracellular matrix, proteases, and cytokines to correlate with computational predictions. Primary focus – image analysis and histopathology.
Computational_Hemodynamics
Working with colleagues in our medical school, we use patient-specific computational models to study vascular disease mechanisms and their treatment. Primary focus - to use image reconstruction methods to create large scale computational models.
Mechanobiological
Assessments using Cell / Tissue Culture – We subject cultured cells and tissue engineered constructs to well defined mechanical stimuli and assess their mechanobiological responses. Primary focus – cell and tissue culture methods.
Computer-aided_Experimentation
We use custom computer-controlled devices to perform theoretically motivated experiments. Primary goal – to design, build, and test new testing systems.
Calibrated_fMRI_for_basal_metabolism
Simulation studies to assess sensitivities required for fMRI and perfusion data to extract basal metabolism from calibrated fMRI data
Quantitative_metabolic_PET
Analysis of whole brain PET data of glucose and oxidative metabolism in the human brain in relation to blood flow
Liposomal_BIRDS
Development and/or characterization of newly developed probes encapsulated inside liposomes for BIRDS
Dendrimeric_BIRDS
Development and/or characterization of newly developed macromolecular-based probes for BIRDS
First_Project
The text about your first project goes in a paragraph like this. Note the format of the title must match the link ("anchor") exactly in the table, above.
Second_Project
Third_Project
Fourth_Project