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Imaging Drugs in the Brain ---
Fall 2010 Syllabus --- ENAS 880 / NSCI
532 ---- Yale University |
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day |
date |
class # |
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Topic |
Author |
Journal |
Year |
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key: |
Lecture (L): |
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Methodology paper (MP): |
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Application paper (AP): |
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Other reading material (OR): |
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Tues |
7-Sep |
1 |
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Overview, course organization,
expectaions |
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Lecture 1: |
Intro to PET/dynamic data/functional imaging |
<-- (right click to download
ppt file) |
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Examples |
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Good overview paper to read
before coming to first class |
Imaging
the Addicted Brain |
Fowler et al. |
Science & Practice
Perspectives |
2007 |
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Tues |
14-Sep |
2 |
(L): |
Receptors/receptor tracers/kinetic models |
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A
Quantitative Model for the In Vivo Assessment of Drug Binding Sites with
Positron Emission Tomography |
Mintun et al. |
Ann Neurol |
1984 |
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papers to be discussed this week
--> |
(AP): |
Imaging
Dopamine Receptors in the Human Brain by Positron Tomography. |
Wagner et
al |
Science |
1983 |
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(OR): |
Quantitative
analysis of D2 dopamine receptor binding in the
living human brain by PET |
Farde L, Hall H, Ehrin E, et al |
Science |
1986 |
231: 258-61 |
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Tues |
21-Sep |
3 |
(L): |
Displacement of tracers by neurotransmitters |
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Effects of
endogenous dopamine on measures of [18F]N-methylspiroperidol binding in the
basal ganglia: Comparison of simulations and experimental results from PET
studies in baboons. |
Logan et
al |
Synapse |
1993 |
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papers to be discussed this week
--> |
(AP): |
Evidence
for Striatal Dopamine Release During a Video Game |
Koepp et al, |
Nature |
1998 |
vol 393 |
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(OR): |
In vivo imaging of
neuromodulation using PET: Optimal ligand characteristics and task length for
detection of activation |
Morris et al, |
Human Brain Mapping |
1995 |
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Tues |
28-Sep |
4 |
(L): |
Intro to Equilibrium Kinetics: Bolus vs
Bolus/Infusion |
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Nicotine-induced
dopamine release in primates measured with [11C]raclopride PET. |
Marenco et al |
Neuro-psychopharm |
2004 |
29(2):259-68 |
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papers to be discussed this week
--> |
(MP): |
PET physiological
measurements using constant infusion. |
Carson |
Nuc Med Biol |
2000 |
657-60 |
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(OR): |
Measurement
of dopamine release with continuous infusion of [11C]raclopride: optimization
and signal-to-noise considerations |
Watabe |
J Nucl Med |
2000 |
Mar;41(3):522-30 |
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Review article |
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Tues |
5-Oct |
5 |
(L): |
Nicotine self
administration, monkeys, receptors |
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this paper is referred to by the
latter LeFoll paper: --> |
(MP): |
Validation
of an Extracerebral Reference Region Approach for the Quantification of Brain
Nicotinic Acetylcholine Receptors in Squirrel Monkeys with PET and
2-18F-Fluoro-A-85380 |
LeFoll et al |
J Nucl Med |
2007 |
48:1492–1500 |
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papers to be discussed this week
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Social dominance in monkeys: dopamine D2
receptors and cocaine self-administration |
Morgan et al |
Nature Neurosci |
2002 |
5(2) 169:174 |
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(OR): |
Baseline Expression of a4b2* Nicotinic
Acetylcholine Receptors Predicts Motivation to Self-administer nicotine |
LeFoll et al |
Biol Psychiatry |
2009 |
65:714-716 |
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Review article |
PET Imaging of Dopamine D2 Receptors in
Monkey Models of Cocaine Abuse:Genetic Predisposition Versus Environmental
Modulation |
Nader and Czoty |
Am J Psychiatry |
2005 |
162:1473-1482 |
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Tues |
12-Oct |
6 |
(L): |
Glucose Utilization and FDG imaging with PET |
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interview
with Lou Sokoloff (video) |
(MP): |
The [14C]deoxyglucose method for
the measurement of local cerebral glucose utilization: theory, procedure, and
normal values in the conscious and anesthetized albino rat. |
Sokoloff
et al |
J Neruochem |
1977 |
28(5):897-916 |
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later review of the classic |
Fluorine-
18-Fluorodeoxyglucose PET to Determine regional cerebral glucose utilization
- a re-examination |
Schmidt, Lucignani and Sokoloff |
J Nucl Med |
1996 |
37: 394-399 |
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Cocaine-Induced
Reduction of Glucose Utilization in Human Brain |
London et al |
Arch Gen Psychiatry |
1990 |
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(OR): |
The
effects of cocaine: A shifting target over the course of addiction |
Porrino |
Progress in Neuro-Psychopharm
& Biol Psych |
2007 |
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Tues |
19-Oct |
7 |
(L): |
Nicotine/Smoking PET &
SPECT part a |
part b |
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(MP): |
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beta2-Nicotinic
acetylcholine receptor availability during acute and prolonged abstinence
from tobacco smoking. |
Cosgrove et al |
Arch Gen Psychiatry |
2009 |
Jun;66(6):666-76 |
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(AP): |
Smoking-induced
ventral striatum dopamine release. |
Brody et al |
Am J Psychiatry |
2004 |
Jul;161(7):1211-8. |
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these 3 papers are similar - lets
compare designs and results re DA |
(AP): |
The
hedonic response to cigarette smoking is proportional to dopamine release in
the human striatum as measured by positron emission tomography and
[11C]raclopride. |
Barret et al |
Synapse |
2004 |
Nov;54(2):65-71. |
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(AP): |
Smoking
Modulation of mu-Opioid and Dopamine D2 Receptor-Mediated Neurotransmission
in Humans |
Scott |
Neuropsychopharm |
2007 |
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(OR): |
Pharmacology of nicotine:
addiction, smoking-induced disease, and therapeutics. |
Benowitz NL. |
Annu Rev Pharmacol Toxicol |
2009 |
49:57-71 |
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another review |
In
vivo brain imaging of human exposure to nicotine and tobacco |
Sharma and Brody |
in NIC PHARM |
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Tues |
26-Oct |
8 |
(L): |
Alcohol/Cues/Drinking/Reward |
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possibly some tidbits here - not
overly relevant but perhaps a good introductory article |
(MP): |
Positron
emission tomography--a tool for identifying the effects of alcohol dependence
on the brain. |
Wong et al |
Alcohol Res Health |
2003 |
27(2):161-73 |
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Sex
Differences in Striatal Dopamine Release in Young Adults After Oral Alcohol
Challenge: A Positron Emission Tomography Imaging Study With [11C]Raclopride |
Urban et al |
Biol Psychiatry |
2010 |
689-96 |
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these 3 papers are similar - lets
compare designs and results re DA |
(AP): |
When
What You See Isn’t What You Get: Alcohol Cues, Alcohol Administration,
Prediction Error, and Human Striatal Dopamine |
Yoder et al |
ACER |
2009 |
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Special Guests! |
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(AP): |
Alcohol
promotes dopamine release in the human nucleus accumbens. |
Boileau |
Synapse |
2003 |
49(4):226-31. |
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Tues |
2-Nov |
9 |
(L): |
Sex
Differences / Drugs / Imaging |
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(MP): |
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(AP): |
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(OR): |
Evolving knowledge of sex
differences in brain structure, function, and chemistry |
Cosgrove |
Biol Psychiatry |
2007 |
847-55 |
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Sex differences in amphetamine-induced... |
Riccardi |
A J Psychiatry |
2006 |
163:1639 |
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papers to be discussed this week
--> |
(AP): |
Sex differences in striatal dopamine release
in ... |
Munro |
Biol Psychiatry |
2006 |
59:966 |
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(AP): |
Dopaminergic
network differences in human impulsivity |
Buckholtz |
Science |
2010 |
329:532 |
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(Suppl): |
Dopaminergic network ... (Online
material) |
Buckholtz |
Science |
2010 |
329:532 |
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Tues |
9-Nov |
10 |
(L): |
Serotonin/Tryptophan Depletion |
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(OR): |
Effects of endogenous
neurotransmitters on the in vivo binding of dopamine and 5-HT radiotracers in
mice |
Rice |
Neuropsychopharm |
2001 |
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Comparison of [18F]altanserin for PET
inaging of serotonin (2A) reeptors in baboon brain: pharmacological studies |
Staley |
Nucl Med Biol |
2001 |
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papers to be discussed this week
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(AP): |
5-HT(1A) receptor imaging in the human
brain: effect of tryptophan depletion and infusion on [(18)F]MPPF binding |
Udo de Haes |
Synapse |
2002 |
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(AP): |
Effects of reduced endogenous 5-HT on
the in vivo binding of the serotonin transporter radiolaigand 11C-DASB in
healthy humans |
Talbot |
Synapse |
2005 |
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Tues |
16-Nov |
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(Eearly) FALL RECESS - NO CLASS |
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Tues |
23-Nov |
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Fall Recess (really!) No Class |
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Tues |
30-Nov |
11 |
(L): |
Modeling Neurocircuitry with
PET: Role of Dopamine in Cocaine Abuse |
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Imaging
dopamine’s role in drug abuse and addiction |
Volkow et al |
Neuropharmacology |
2009 |
56(Suppl 1): 3–8 |
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(AP): |
Elevated
Striatal Dopamine Transporters During Acute Cocaine Abstinence as Measured by
[123I]b-CIT SPECT |
Malison et al |
Am J Psychiatry |
1998 |
155:832:834 |
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papers to be discussed this week
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(AP): |
Amphetamine-induced
dopamine release: markedly blunted in cocaine dependence and predictive of
the choice to self-administer cocaine. |
Martinez D,et al. |
Am J Psychiatry |
2007 |
Apr;164(4):622-9. |
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(OR): |
Increased
Occupancy of Dopamine Receptors in Human Striatum during Cue-Elicited Cocaine
Craving |
Wong et al |
Neuropsychopharmacology |
2006 |
31, 2716–2727 |
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Tues |
7-Dec |
12 |
(L): |
Drug
Development/Receptor Occupancy |
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The
slow and long-lasting blockade of dopamine transporters in human brain
induced by the new antidepressant drug radafaxine predict poor reinforcing
effects. |
Volkow et al |
Biol Psych |
2005 |
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papers to be discussed this week
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(AP): |
Dopmine D2
receptor occupancy by perospirone... |
Arakawa et
al |
J Clin Psychopharm |
2010 |
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(AP): |
Striatal and extrastriatal D2/D3
receptor binding properties of Ziprasidone |
Vernaleken et al |
Psychopharm |
2008 |
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Review: |
Approaches
using molecular imaging... PET in Clinical microdose studies |
Wagner |
Adv Drug Deliv Reviews |
2010 |
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Tues |
14-Dec |
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FINAL EXAM |
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Reference
Books |
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(some of these may be
available in the |
Yale
Online catalogue) |
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Imaging in
Drug Discovery and Early Clinical Trials |
Rudin |
Birkhauser |
2005 |
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Nicotine
Psychopharmacology (NIC PHARM) |
Henningfield et al |
Springer |
2009 |
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Methods in
Alcohol-Related Neuroscience Research |
Liu & Lovinger |
CRC |
2002 |
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Brain
Mapping, The Methods |
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Toga, Mazzziota |
Academic |
2002 |
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Introduction
to Functional Magnetic Resonance Imaging |
Buxton |
Cambridge |
2002 |
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functional
MRI |
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Moonen |
Springer |
1999 |
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Quantitative
MRI of the Brain |
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Tofts |
Wiley |
2003 |
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Introduction
to the Science of Medical Imaging |
Bryan |
Cambridge |
2010 |
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Review articles for
Background Reading |
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Imaging
Modalities: principles and information content |
T Schaeffter |
in "Imaging in Drug
Discovery …" |
2005 |
17-81 |
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Dopamine in
drug abuse and addiction: results from imaging studies and treatment implications |
Volkow et al |
Molecular Psychiatry |
2004 |
9,
557–569 |
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to be rescheduled: |
SPECT |
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(L): |
Applications of SPECT imaging of
dopaminergic neurotransmission in neuropsychiatric disorders. |
Kugaya A, Fujita M, Innis RB. |
Ann Nucl Med. |
2000 |
Feb;14(1):1-9 |
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(MP): |
SPECT imaging of striatal
dopamine release after amphetamine challenge. |
Laruelle et al. |
J Nucl Med |
1995 |
Jul;36(7):1182-90 |
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(AP): |
Behavioral changes and
[123I]IBZM equilibrium SPECT measurement of amphetamine-induced dopamine
release in rhesus monkeys exposed to subchronic amphetamine. |
Castner SA et al |
Neuropsychopharmacology |
2000 |
Jan;22(1):4-13. |
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(OR): |
Positron and Single Photon
Emission Tomography: Principles and applications in psychopharmacology |
Malison et al |
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to be rescheduled: |
fMRI |
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(L): |
selections from Buxton |
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(MP): |
Association of nicotine
addiction and nicotine's actions with separate cingulate cortex functional
circuits |
Hong et al. |
Arch Gen Psychiatry |
2009 |
66(4):431-41 |
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(AP): |
Magnetic Resonance Imaging
Studies of Cigarette Smoking |
Azizian et al |
in "Nicotine
Psychopharmacology" |
2009 |
113-143 |
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to be rescheduled: |
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(L): |
Cocaine Abuse |
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(MP): |
Euphorigenic doses ofcocaine
reduce [123I] beta-CIT SPECT measures of dopamine transporter availability in
human cocaine addicts |
Malison RT, Best SE, Wallace
EA, et al. |
Psychopharmacology (Berl) |
1995 |
122: 358-62 |
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(AP): |
Amphetamine-induced dopamine
release: markedly blunted in cocaine dependence and predictive of the choice
to self-administer cocaine. |
Martinez D,et al. |
Am J Psychiatry |
2007 |
Apr;164(4):622-9. |
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(OR): |
Cocaine abuse and sensitization
of striatal dopamine transmission: a critical review of the preclinical and
clinical imaging literature. |
Narendran R, Martinez D |
Synapse |
2008 |
Nov;62(11):851-69 |
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