BME faculty Senior Projects List 2014

BME Faculty List of Possible Senior Projects

Note to studdents. Any faculty member who is listed in this matrix has projects currently avaialable for juniors and seniors in BME

Faculty Member	Lab Description	Track	Location	Project title	Project title	Project title	Project title
Humphrey, Jay	Vascular Mechanics and Mechanobiology Lab	Biomechanics	Malone	Quantitative Histology	Computational Hemodynamics	Mechanobiological Assessments using Cell / Tissue Culture	Computer-aided Experimentation
Morris, Evan	Neuroimaging of Addiction and Medications Development	Imaging	PET Center, LMP (Medical Campus)	Modeling Dopamine Response to Smoking Cigarettes	Action of Naltrexone to treat alcoholism	Imaging Opioid Receptors in Mood Disorders	Imaging a human model of fatigue
Duncan, Jim
Carson, Rich
Saltzman, Mark
Liu, Chi
Constable, Todd
Staib, Larry

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Lab Descriptions

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Humphrey – Vascular Mechanics and Mechanobiology Lab (Biomechanics Track) Our focus is on (i) developing computational models for understanding vascular disease progression and designing clinical interventions, (ii) using genetic, pharmacologic, and surgical models to elucidate mechanisms that underlie diverse vascular conditions, and (iii) using tissue engineered constructs to test hypotheses of mechanosensing and mechanoregulation of extracellular matrix.

Project Descriptions

Quantitative Histology

We use histology and immunohistology to quantify regional variations in the distributions of vascular cell phenotype, extracellular matrix, proteases, and cytokines to correlate with computational predictions. Primary focus – image analysis and histopathology.

Computational Hemodynamics – working with colleagues in our medical school, we use patient-specific computational models to study vascular disease mechanisms and their treatment. Primary focus - to use image reconstruction methods to create large scale computational models.

Mechanobiological Assessments using Cell / Tissue Culture – we subject cultured cells and tissue engineered constructs to well defined mechanical stimuli and assess their mechanobiological responses. Primary focus – cell and tissue culture methods.

Computer-aided Experimentation – we use custom computer-controlled devices to perform theoretically motivated experiments. Primary goal – to design, build, and test new testing systems.

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