Virtual Journal Club

(download the pdf, email me your comments and I'll post them here!)

Current Paper (June 21, 2001):
Delforge et al, JCBF&M 21:613-630, June 2001 "Absolute Quantification by PET of the Endogenous Ligand"

Comments:

1. Evan's Initial Comments on Delforge 2001.

Possible future papers:
 

Logan et al. JCBF&M 2000

Gunn et al.  JCBF&M 2001. Positron Emission Tomography Compartmental Models.

Classic PET papers related to Endogenous Neurotransmitters

Koepp et al, Nature vol 393, 1998, "Evidence for Striatal Dopamine Release During a Video Game"

Breier et al, PNAS 1997 (94):2569-2574. Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel PET method

Logan et al. Synapse 27:344-356, 1997.  Concentration and Occupancy of Dopamine Transporters in Cocaine Abusers with 11C-Cocaine and PET.

Contradictory results from studies on cocaine-induced-euphoria and DAT occupancy level

Malison RT, et al. Psychopharmacology (Berl) 1995 Dec;122(4):358-62  Euphorigenic doses of cocaine reduce [123I]beta-CIT SPECT measures of dopamine transporter availability in human cocaine addicts.

Volkow ND et al, Synapse 399-402, 1996.   Cocaine doses equivalent to those abused by humans occupy most of the dopamine transporters. (not even an abstract available online - sorry)

Microdialysis and PET/SPECT

Laruelle et al., Synapse 25, 1-14, 1997 Microdialysis and SPECT Measurements of Amphetamine-Induced Dopamine Release in Non-human Primates.     CHECK OUT FIGURE 3.

Endres and Kolchana and Saunders et al, JCBF&M 17,932-42, 1997. Kinetic Modeling of 11C-raclopride: combined PET-mcrodialysis studies

(repeated from above)
Breier et al, PNAS 1997 (94):2569-2574. Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel PET method

Measuring some other neurotransmitter by its effect on Dopamine

Smith GS and Dewey SL et al., AJPsychiatry 154:490-496, 1997.  Serotonergic modulation of dopamine measured with 11C-Raclopride and PET in Nomrmal Human Subjects.

Review Articles on Imaging Neurotransmitters and NeuroReceptors with PET and SPECT (abstracts only available on-line)

Kegeles LS, Mann JJ. Neuropsychopharmacology 1997 Nov;17(5):293-307 In vivo imaging of neurotransmitter systems using radiolabeled receptor ligands.

Laruelle M.. J Cereb Blood Flow Metab 2000 Mar;20(3):423-51 Imaging synaptic neurotransmission with in vivo binding competition techniques: a critical review.

Alcohol and Imaging

Mann K et al. Alcoholism: Cliical and Experimental Research 25(5) May Suppl 2001 Neuroimaging in alcoholism: Ethanol and brain damage

Studies using Multiple-Injection PET
 

1.  Poyot T, Conde F, Gregoire MC, et al.. J Cereb Blood Flow Metab. 2001 Jul;21(7):782-92. Anatomic and biochemical correlates of the dopamine transporter ligand 11C-PE2I in normal and parkinsonian primates: comparison with 6-[18F]fluoro-L-dopa.