Welcome
to the new homepage for
quick links
department links
News:
Evan winds 2013 Yale Graduate Mentor Award for Natural Sciences (pics) (video) (speech text)
Jenna and friends receive Doctoral diplomas May 20, 2013
Shuo presents poster at BrainPET in Shanghai, May 2013
Sujin's paper on selectivity of 11C-pkab published in J Nucl Med
Yale PET Center featured in monthly Medicine@Yale magazine. Read article here (March 2013)
Jenna's paper on limitations of conventional models for describing transient dopamine events published in AJNMMI
Jenna Sullivan successfully defends PhD thesis (Dec 2012)
Successful end to Fall Semester, 2012. Read what people are saying about ENAS-880 (2012)
Morris Lab receives NIH grant for "Dynamic Dopamine Images: A New View of the Neurochemistry of Smoking
(Sept 2012)
Posters presented by our group at recent Neuroreceptor Mapping Meeting (Aug 2012)
Evan presents "PET Talks!" on Intro to PET Analysis to packed house, June 2012 (video)
Jenna Sullivan, Su Jin Kim win Young Scientist
Awards for submissions to Neuroreceptor Mapping Meeting summer 2012 in
Baltimore. (Program)
Successful end to Fall Semester, 2011. Read what people are saying about ENAS-880 (2011)
Sept 10, 2011: Evan completes "Closer to Free" 100 mile bike ride in 7:09:30 + rest stops. Raises $1750 for Smilow Cancer Hospital.
Cool Images
Dopamine Multi-Movie of cigarette smoking!
Lab photo from first cookout of 2013
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Jump to Infrequently Asked PET questions Jump to other Quick-links
Current Affiliations
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| Yale Psychiatry Dept |
Monthly PET TALKS! |
| Interdepartmental Neuroscience Program |
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Contact |
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Evan's
Smoking Questionaire (v4) (this is correct as of 11/12/11) |
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Human Research Study Participant Advance Request (for rac_pd) |
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| How to split the Dose (xls) |
Physical Exam Forms (pdf) | ||
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Smoking Checklist |
For PET PIs (soon to be available through main Yale PET website)
| Protocol Initiation Form (trial online version - this is under development) |
sends data to prot_init.cgi |
| will send data to pet.scheduling@yale.edu | |
| Prorocol Intiation Form (trial online version 3) |
Seminar Series
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Answers to In-frequently Asked PET
Questions
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BIO
Evan D. Morris, PhD has been working in the field of PET and functional imaging for 20 years. He specializes in kinetic
modeling of dynamic image data. He was trained as a biomedical engineer
and before that as a chemical engineer. In the past, he has taught courses at
the undergraduate and graduate levels in Medical Imaging, Tracer Kinetics,
Biomedical Transport, and Biomedical Ethics, among others. For more info about
his past classroom teaching at Indiana University, Purdue University at
Indianapolis (IUPUI), including online lectures (video and Powerpoints)
for some courses, please follow the link to his IUPUI
website. Morris joined the
Dr
Morris and his students have been working on kinetic models to estimate the
dynamics of endogenous neurotransmitters from PET data. A recent publication in Neuroimage in
2010 demonstrated a novel analysis strategy for creating the first
ever “movies” of dopamine action in the living brain. The movies
can be viewed here (movie of "early"
finger-tapping, movie of "late"
finger-tapping). Altered neurotransmitter kinetics may explain the
mechanism of addiction of some drugs. This work
uses knowledge of numerical methods, biochemistry, image and signal
processing, parameter estimation, and programming. An earlier
paper in Molecular Imaging and Biology compared the
estimates of dopamine curves from fitting models to PET data to direct microdialysis measurements. A collection of papers to
result from this project can be downloaded as a zip file here. (~8Mb) The
work was funded by the Whitaker Foundation and the National Institute on
Alcohol Abuse and Alcoholism.
While
in
<>Interests
Prof. Morris is currently interested in the use of PET imaging (of people and
animals) with neuroreceptor tracers to understand and
improve treatments for Parkinson’s disease, alcoholism, smoking, and drug
abuse.
Current Active Projects (all use PET imaging and some type(s) of mathematical modeling)
2. Are kappa opiate receptors important in the treatment of alcoholism?
3. What is the role of dopamine in common medication-related side effects of treatments for Parkinson's disease?
4. Can depletion of dopamine be detected with PET and can this be an assay for upstream activation of other neurotransmitter systems?
5. What models are best for characterizing the uptake and retention of the mGluR5 tracer, 18F-fpeb ?
6. Can we detect glutamate release with the PET tracer, 18F-fpeb
Job Opportunities
1. Many opportunities for students to do research rotations. Please email Dr Morris
Other ongoing
interests of Prof Morris:
Small animal imaging. A recent
paper details the design and validation of a stereotactic head-holder for
imaging two rats in a PET scanner at the same time. The paper was
published in Journal of Neuroscience Methods. Get it here.
Direct reconstruction of PET data to parametric images. This work was a collaboration with colleagues at
<>
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Course Number(s) |
Title (link to
course webpage) |
Semester |
| ENAS 915 |
Tracer Kinetics and Modeling |
Spring 2013 |
| ENAS 880 / NSCI 523 | Imaging Drugs in the Brain | Falll 2012 |
| ENAS 880 / NSCI 523 | Imaging Drugs in the Brain | Falll 2011 |
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ENAS 880 / NSCI 523 |
Fall 2010 |
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ENAS 503 |
Ethics and Professional Development for
Biomedical Scientists and Engineers |
Spring 2011 |
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| Julia and Sujin take a ride along the Farmington canal and find the perfect sign (blue). |
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| Riders before an Aug 2011 training ride to prepare for Closer to Free ride |
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| With Stuart Basseches... somewhere along the Hudson River... on a hot-as-hell ride , July 2011. |
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| Evan and Bob ride from UConn (Storrs, CT) to Welleseley College (Wellesely, MA) June 2012 |
Conference in New Orleans, SNM, June 2008
photo grid
Lecture in Turku, Turku PET symposium, June 2008
photo grid (Turku)
photo grid (Talin,
Estonia)
Lecture in Copenhagen METPETS consortium, June 2009
photo grid
photo grid 2
(commuting in Copenhagen)
Lecture in Chicago, BrainPET, 2009
photo grid
Lecture at Univ Washington, Seattle, June 2010
photo grid - Seattle
photo grid -
Victoria, BC
Lecture at Univ Glasgow, July 2010
photo grid
Lecture at Bogazici University (Biomedical
Institute), Istanbul, Nov 2010
Photos
Lecture at Hadassah Hospital, Jerusalem, Nov 2010
Photos
Lecture at Univ Wisconsin, Madison, Nov 2010
Photos
Lecture at Mass General Hospital, Boston, Dec 2010
BS, BS (Chemical Engineering, Biology) MIT
MS, PhD, (Biomedical Engineering)
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