Welcome to the new homepage for Evan D. Morris, PhD,            Yale University

The home of "lp-ntPET" - the model that allows us to make "dopamine movies" from PET data!
Click here for related articles. Click here for Video tutorial. Click here for example movies (see Kim et al 2014 for explanation).


                                                                                         News     Quick links        Courses            Evan's favorites
                                                                                         Department links             Main links        PET Talks!


 



Evan D, Morris, PhD
Assoc. Prof
Diagnostic Radiology,
Psychiatry,
Biomedical Engineering
Co-Director of Imaging Section
Yale PET Center
Yale University

evan.morris AT yale.edu


Other webpages for Evan

Radiology


Engineering


Old IUPUI site

 

evan in Scotland

 

Contact

sending (US) mail to
Yale PET Center

P.O. Box 208048
New Haven, CT 06520-8048





        
        
Current Affiliations

Yale University

Yale PET Center External Site

 

Yale PET Center Internal Site (password required)

Yale Biomedical Engineering Dept.

Yale PET Center Internal Wiki (password required)

Yale Diagnostic Radiology Dept

Yale PET Center Public Wiki

Yale Bioimaging Sciences


Yale Psychiatry Dept
Monthly PET TALKS!
Interdepartmental Neuroscience Program

Yale Cancer Center




News:


(click on icons or text)




Ryan's findings with 11C-erlotinib for imaging  lung cancer are featured in summary talk at SNM 2014 in St Louis
June 2014

.
money
Sarah Goldberg, Joe Contessa and Evan receive core pilot funding from YCCI to scan monkeys and humans with 11C-erlotinib May 2014
hbm

Sujin and friends publish mathematical basis for dopamine movies in Human Brain Mapping
Mar 2014


video


Evan gives Grand Rounds at Yale Cancer Center. (video)
Mar 2014
yjbm Evan, Molly, Ryan, Kelly, publish review paper on PET Experiments and studies of drinking in Yale Journal of Biology and Medicine  Feb 2014
nrm2014

Shuo and Ryan and other lab alumni have abstracts accepted to NRM 2014.
Feb 2014

Shuo and ACSSY host Gala Celebration of Chinese New Years - see photos. Jan 2014
book Evan, Kelly and Molly Lucas publish an introductory book chapter "How to Study Smoking and Drinking with PET" Dec 2013




blackboard Successful end to fall semester 2013. Read what people are saying about ENAS-880.
Dec 2013



Shuo Wang passes her Area Exam!
Nov 20, 2013
neoplasia
Ryan Petrulli, Joe Contessa and friends have first paper accepted on imaging of mutant EGFR with 11C-erlotinib
Nov 11, 2013

money
Morris lab (and Hannestad) receives NIH grant, "Endotoxin-induced inflammation affects striatal dopamine: A raclopride PET study"  Sept 2013

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Evan to run Phase 1 trial as part of multi-center consortium, "New Experimental Medicine Studies: Fast-Fail Trials in Mood and Anxiety Spectrum Disorders" Aug 2013

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Morris and Krishnan-Sarin Labs jointly receive NIH grant "PET imaging of Naltrexone Occupancy of Kappa Receptors in Heavy Drinkers" July 2013
video Morris, Cosgrove and friends publish video article on making dopamine movies in Journal of Visualized Experiments. (video) Jun 2013
nida
Prof. Kelly Cosgrove's work featured in NIDA online publication, "The Science of Drug Abuse and Addiction" May 2013

video Evan wins 2013 Yale Graduate Mentor Award for Natural Sciences (pics) (YouTube) (download video) (speech text) (SEAS news item) May 2013

Jenna and friends (with another friend) receive Doctoral diplomas May 20, 2013

Shuo Wang presents poster at BrainPET in Shanghai May 2013
blackboard

Successful end to Spring Semester, 2013. Read what people are saying about ENAS-915 "Tracer Kinetics" (coming soon)
Apr 2013
jnm
Su Jin Kim's paper on selectivity of 11C-pkab accepted for publication in J Nucl Med
Apr 2013
ysm

Yale PET Center featured in monthly Medicine@Yale magazine. Read article here
March 2013
ajnmmi
Jenna's paper on limitations of conventional models for describing transient dopamine events published in AJNMMI
Jan 2013


Jenna Sullivan successfully defends PhD thesis
Dec 2012
blackboard
Successful end to Fall Semester, 2012.  Read what people are saying about ENAS-880 (2012) Dec 2012
money Morris Lab receives NIH grant for "Dynamic Dopamine Images: A New View of the Neurochemistry of Smoking" Sept 2012

Posters presented by our group at recent Neuroreceptor Mapping Meeting Aug 2012
video
Evan presents "PET Talks!" on Intro to PET Analysis to packed house (video)
June 2012

Jenna Sullivan, Su Jin Kim win Young Scientist Awards for submissions to Neuroreceptor Mapping Meeting summer 2012 in Baltimore. (Program) May 2012
blackboard
Successful end to Fall Semester, 2011.  Read what people are saying about ENAS-880 (2011) Dec 2011

closer to free
Sept 10: Evan completes "Closer to Free" 100 mile bike ride in 7:09:30 + rest stops.  Raises $1750 for Smilow Cancer Hospital. Sept 2011



Cool Images


Dopamine Multi-Movie of cigarette smoking!


Group Photos

Photo of Shuo Wang and friend at Chinese New Year's Gala January 2014

Lab photo from first cookout of 2013


Important links:

iupui link
                                        
main links
           Link to old IUPUI website                                                 Main Links




Main Links

science

Recent Publications of

Yale PET Center

next slide please

Recent Presentations

thumb

Evan's NIH biosketch 1/14

thinkerthinker
Research Interests



Short Bio


blackboard
Courses



Current projects





Projects for BME Undergrads





diploma
Education



Trips - and Photos


RCA-dog
PET Talks(s1)  (s2)  (s3)
(lots of videos here!)


Journal Club -


lab group
Lab Group


  Job Opportunities

 book
Book Chapters

Direct Link to Most
Recent Papers

 

tools
PET
Center
Tools

formsformsforms
PET Center Forms

                
 

                                   

Dose-Delivered-by-Infusion (htm)

Evan's Smoking Questionaire (v4) (this is correct as of 11/12/11)

 

 

Dose-Delivered-by-Infusion (xls)

Human Research Study Participant Advance Request (for rac_pd)

 

 

 How to split the Dose (xls)
Physical Exam Forms (pdf)

 
Smoking Checklist


 


For PET PIs (soon to be available through main Yale PET website)

Protocol Initiation Form (trial online version - this is under development)
sends data to prot_init.cgi
will send data to pet.scheduling@yale.edu            
Prorocol Intiation Form (trial online version 3)




Seminar Series

PET talks

Biomedical Engineering  Seminars (Grad students and Outside guests) 

 

 

Bioimaging Sciences

INP student seminars

 

 

fMRI  seminars

 

 

 


Answers to In-frequently Asked PET Questions

When should we administer a dopaminergic stimulus relative to an injection of 11C-raclopride to get a maximal change in BP?

 

 

 

 

 

 

 

 

 

BIO
Evan D. Morris, PhD has been working in the field of PET and functional imaging  for 20 years.  He specializes in kinetic modeling of dynamic image data.  He was trained as a biomedical engineer and before that as a chemical engineer. In the past, he has taught courses at the undergraduate and graduate levels in Medical Imaging, Tracer Kinetics, Biomedical Transport, and Biomedical Ethics, among others. For more info about his past classroom teaching at Indiana University, Purdue University at Indianapolis (IUPUI), including online lectures (video and Powerpoints) for some courses, please follow the link to his IUPUI website.  Morris joined the Yale PET Center as Co-Director of the Imaging Section in the fall of 2009.


Dr Morris and his students have been working on kinetic models to estimate the dynamics of endogenous neurotransmitters from PET data.  A recent publication in Neuroimage in 2010 demonstrated a novel analysis strategy for creating the first ever “movies” of dopamine action in the living brain. The movies can be viewed here (movie of "early" finger-tapping, movie of "late" finger-tapping).  Altered neurotransmitter kinetics may explain the mechanism of addiction of some drugs.  This work  uses knowledge of numerical methods, biochemistry, image and signal processing, parameter estimation, and programming.  An earlier paper in Molecular Imaging and Biology compared the  estimates of dopamine curves from fitting models to PET data to direct microdialysis measurements.  A collection of papers to result from this project can be downloaded as a zip file here. (~8Mb)  The work was funded by the Whitaker Foundation and the National Institute on Alcohol Abuse and Alcoholism.


While in Indiana, Morris and his colleagues focused much of their efforts on the use of PET to understand what makes drugs and alcohol addictive.  Their most recent publication in Alcoholism, Clinical and Experimental Research in 2009 is here.  It represents the first demonstration in humans of the neurochemistry of reward prediction error.  This work uses knowledge of neuropsychology, image processing, experimental study design, neurochemistry, and kinetic modeling.


<>Interests
Prof. Morris is currently interested in the use of PET imaging (of people and animals) with neuroreceptor tracers to understand and improve treatments for Parkinson’s disease, alcoholism, smoking, drug abuse and cancer.

 

Current Active Projects (all use PET imaging and some type(s) of mathematical modeling)

1. Are kappa opiate receptors important in the treatment of alcoholism?

2. Is there a spatio-temporal  pattern of dopamine activation in the brain that represents the signature of addiction?

3. Are kappa antagonists viable medications for the treatment of depression?

4.  Is there a dopaminergic component to processing taste that is relatd to obesity?

5.  What is the precise molecular target of the cancer drug erlotinib that is used to treat lung cancer

6. Is there a dopaminergic component to fatigue? And does that help us develop medications for fatigue?

7. The first time people get scanned in the PET scanner, they may be feeling nervous, they are experiencing the novelty of it!
Lets build a "mock PET scanner" to get people accustomed to the scanner before the  first scan.

8.  How does the pattern of activation in your brain change as your addiction progresses or regresses.
Lets invent a way to visualize change in brain patterns over time.

Job Opportunities

1. Many opportunities for students to do research rotations.  If you are a BME student or an INP student and need a rotation, please email Dr Morris


Other ongoing interests of Prof Morris:

Small animal imaging. A recent paper details the design and validation of a stereotactic head-holder for imaging two rats in a PET scanner at the same time.  The paper was published in Journal of Neuroscience Methods. Get it here.

Direct reconstruction of PET data to parametric images.  This work was a collaboration with colleagues at Purdue University and used knowledge of kinetic modeling, imaging physics, optimization and algorithm design.  It yielded the first working algorithm to create parametric images of the four kinetic parameters of the two-tissue model directly from raw (sinogram) data.  The primary paper to result from this collaboration was published in IEEE Transactions on Medical Imaging and can be downloaded here.   A new publication  is currently "in press" in  IEEE TMI on this topic.


COURSE LIST

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Course Number(s)

Title  (link to course webpage)

Semester

ENAS 915
Tracer Kinetics and Modeling
Spring 2013



ENAS 880 /  NSCI 523
Imaging Drugs in the Brain
Fall 2013
ENAS 880 /  NSCI 523 Imaging Drugs in the Brain Falll 2012
ENAS 880 /  NSCI 523 Imaging Drugs in the Brain Falll 2011

ENAS 880 /  NSCI 523

Imaging Drugs in the Brain

Fall 2010




ENAS 503

Ethics and Professional Development for Biomedical Scientists and Engineers

Spring 2011


<>

Trips  - and Photos

sujin and julia 201
Julia and Sujin take a ride along the Farmington canal and find the perfect sign (blue).
training ride 201
Riders before an Aug 2011 training ride to prepare for Closer to Free ride
ride with stuart
With Stuart Basseches... somewhere along the Hudson River... on a hot-as-hell ride , July 2011.
welcome to MA
Evan and Bob ride from UConn (Storrs, CT) to Welleseley College (Wellesely, MA) June 2012


Conference in New Orleans, SNM, June 2008
           photo grid
Lecture in Turku, Turku PET symposium, June 2008
           photo grid (Turku)
           photo grid (Talin, Estonia)
Lecture in  Copenhagen METPETS consortium, June 2009
          photo grid
          photo grid 2 (commuting in Copenhagen)
Lecture in Chicago, BrainPET, 2009
          photo grid
Lecture  at Univ Washington, Seattle, June 2010
          photo grid - Seattle
          photo grid -  Victoria, BC
Lecture at  Univ Glasgow, July 2010
          photo grid
Lecture at Bogazici University (Biomedical Institute), Istanbul, Nov 2010
          Photos
Lecture at Hadassah Hospital, Jerusalem, Nov 2010
          Photos
Lecture at Univ Wisconsin, Madison, Nov 2010
          Photos
Lecture at Mass General Hospital, Boston, Dec 2010



EDUCATION

BS, BS (Chemical Engineering, Biology) MIT
MS, PhD, (Biomedical Engineering) Case Western Reserve University
Postdoctoral Fellowship, (Radiological Sciences) MGH/Harvard



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Recommended links

Taste of Beer Prompts Dopamine Release